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. 2020 Jul 6;12(7):1813. doi: 10.3390/cancers12071813

Figure 1.

Figure 1

Functional roles of PARP1 in nucleolar biology. DDX21, DEAD-box helicase 21; DNA-PK, DNA-dependent protein kinase; NoRC, nucleolar remodeling complex; PAR, poly(ADP-ribose); PARP1, poly(ADP-ribosyl) polymerase 1; Pol I, polymerase I; pRNA, promotor-associated RNA; rDNA, ribosomal DNA; rRNA, ribosomal RNA; snoRNA, small nucleolar RNA; TIP5, TTF-1-interacting protein 5; UBF, upstream binding factor; WRN, Werner syndrome protein; XRCC1, X-ray repair cross complementing 1. For details see Section 4.