Figure 3.

Color fundus, auto-fluorescence (AF), and indocyanine green angiography (IA) images before and at 1 year after the iPS cells-derived RPE cell transplantation in two cases. Representative fundus images during the 1-year follow-up are shown for Case 1 (A) and Case 2 (D). After surgery, grafted RPE cells were seen in the subretinal space around 3 and 8 weeks, respectively. Pigmented cells became visible by 6 months after the transplantation with a stable pigmented area observed at 1 year in both cases (white arrows). AF images (B,E) show a dark area that corresponds to the grafted cells at 1 year after the transplantation (white arrows). In IA images of Case 1 (C), yellow arrows indicate the presence of polyp lesions before the treatment. After 1 year, Case 1 developed a new polyp that was associated with hemorrhagic lesions on the lower margins of the PCV network (red arrows). On the other hand, there were no changes in the findings of the IA examination in Case 2 as compared with the pretreatment (F).