Figure 3.

Primary BCP-ALL patient samples can be expanded in zebrafish embryos with individual responsiveness to venetoclax. Viability of isolated mononuclear cells from primary bone marrow aspirates engrafted in immunosuppressed zebrafish embryos or in vitro 2D cultures as controls were assessed flow cytometrically after 3 days of exposure to the range of venetoclax concentrations. Graphs for patients 1, 2, 4 and 7 represent one experiment measured as the mean of a pool of 10–20 embryos. Graphs for patients 3 and 5 represent the means from two independent experiments. Error bars represent SEM.