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. 2020 Jul 14;9(7):2228. doi: 10.3390/jcm9072228

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Non-coding RNA modifications and their functional roles in cSCC development: (A) down-regulation of tumor suppressor microRNAs (miRNAs) leads to the overexpression of target genes, while up-regulation of onco-miRNAs has a suppressive effect on specific molecular targets; (B) Dysregulated long non-coding RNAs (lncRNAs) that contribute to tumor progression through abnormal regulation of targeted genes (currently unknown for GAS5); (C) LncRNAs and miRNAs favor cell proliferation, survival, migration, invasion, inflammation, angiogenesis, tumor progression and metastasis in cSCC. Color-coded for involvement in several processes (created in BioRender.com).