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. 2020 Jul 8;12(7):1835. doi: 10.3390/cancers12071835

Figure 2.

Figure 2

Overall survival multivariable regression analysis and risk score assessment. (a) Kaplan–Meier analysis of OS with regard to HEDtotal, considering only patients fully heterozygous for HLA-A, HLA-B, HLA-C, and HLA-DR (n = 126). (b) Multivariable Cox regression analysis of the impact of low HEDtotal on OS. (c) Kaplan–Meier analysis of OS with regard to European Society for Blood and Marrow Transplantation (EBMT) risk score [11] in a simplified adaption into three risk categories. Respective clinical data for risk score calculation was available for 163 patients. (d) Left panel: Inclusion of the risk factor low HEDtotal to the EBMT risk score [11], yielding three major risk categories. Right panel: Kaplan–Meier analysis of OS in the AML patient cohort (n = 163) with regard to the adapted risk score. Abbreviations: HED indicates HLA evolutionary divergence; OS, overall survival; HSCT, hematopoietic stem cell transplantation; HLA-id., HLA-identical; mo, months; EBMT risk score, European Society for Blood and Marrow Transplantation risk score [11]; and #, versus early stage.