Table 1.
Previously published cases of Nocardia paucivorans infection.
| Case n°/Reference | Year ** | Age | Sex | Site | Immune Status | Therapy Regimen | Therapy Duration | Outcome |
|---|---|---|---|---|---|---|---|---|
| 1 [58] | 2000 | 51 | M | Sputum | Chronic lung disease | NR | NR | NR |
| 2 [59] | 2002 | 40 | F | Brain abscess | NR | NR | NR | NR |
| 3 [60] | 2002 | 63 | M | Brain abscess | Low CD4+ count of unknown origin | Cef, Amp, Amk, Mer, Levo, Mino | >6 months | survived |
| 4 [61] | 2006 | 54 | M | Sputum, BAL, lung biopsy | Immunocompetent | TMP/SMX, A/clav, Cip | 6 months | NR |
| 5 [62] | 2006 | 63 | M | Brain abscess | Immunocompetent | Surgical resection, TMP/SMX | 3 months | survived |
| 6 [63] | 2007 | 52 | M | Lung abscess | NR | NR | NR | died |
| 7 [63] | 2007 | 55 | M | Brain abscess | NR | NR | NR | NR |
| 8 [63] | 2007 | NR | M | Pleural fluid | NR | NR | NR | NR |
| 9 [63] | 2007 | 44 | M | Mediastinal lymph node | NR | NR | NR | NR |
| 10 [63] | 2007 | 78 | F | Lung abscess | Chronic lung disease | NR | NR | NR |
| 11 [63] | 2007 | 50 | F | Sputum | NR | NR | NR | NR |
| 12 [63] | 2007 | 41 | M | Brain abscess | Hodgkin’s lymphoma | NR | NR | NR |
| 13 [63] | 2007 | 53 | M | Lung abscess | NR | NR | NR | NR |
| 14 [63] | 2007 | 58 | F | Brain abscess | Corticosteroid therapy | NR | NR | NR |
| 15 [63] | 2007 | 66 | F | Sputum | NR | NR | NR | NR |
| 16 [63] | 2007 | 54 | M | Endocarditis, brain abscess, | NR | NR | NR | NR |
| skin abscess | ||||||||
| 17 [63] | 2007 | 65 | F | Sputum | NR | NR | NR | NR |
| 18 [63] | 2007 | 72 | F | Lung abscess | Corticosteroid therapy | NR | NR | NR |
| 19 [63] | 2007 | 66 | M | Brain abscess | Immunosuppression * | NR | NR | NR |
| 20 [63] | 2007 | 74 | M | BAL fluid | NR | NR | NR | NR |
| 21 [63] | 2007 | NR | M | Sputum | NR | NR | NR | NR |
| 22 [63] | 2007 | 74 | M | Skin abscess | NR | NR | NR | NR |
| 23 [63] | 2007 | 57 | M | Brain abscess, pneumonia | NR | NR | NR | NR |
| 24 [63] | 2007 | 80 | M | Lung, skin | NR | NR | NR | NR |
| 25 [63] | 2007 | 62 | M | Skin | Immunocompetent | NR | NR | NR |
| 26 [63] | 2007 | 87 | M | Sputum | NR | NR | NR | NR |
| 27 [63] | 2007 | 77 | F | BAL fluid | Immunocompetent | NR | NR | NR |
| 28 [63] | 2007 | 50 | M | Sputum | Lung cancer | NR | NR | NR |
| 29 [63] | 2007 | 67 | M | Brain abscess | Diabetes mellitus | NR | NR | NR |
| 30 [63] | 2007 | 67 | M | Sputum | Immunocompetent | NR | NR | NR |
| 31 [63] | 2007 | 47 | F | Sputum | NR | NR | NR | NR |
| 32 [63] | 2007 | 66 | F | Sputum | Previous lung infection | NR | NR | NR |
| 33 [63] | 2007 | 46 | M | Sputum | Immunocompetent | NR | NR | NR |
| 34 [63] | 2007 | 79 | M | Pleural fluid | Corticosteroid therapy | NR | NR | NR |
| 35 [63] | 2007 | 76 | M | Pleural fluid | Immunocompetent | NR | NR | NR |
| 36 [63] | 2007 | 61 | M | Skin abscess | NR | NR | NR | NR |
| 37 [63] | 2007 | 60 | M | Blood | Chemotherapy | NR | NR | NR |
| 38 [63] | 2007 | 53 | M | BAL fluid and skin lesion | Smoking and other drug abuse, Hepatitis C | Tica/clav, Rox, TMP/SMX | 12 months | survived |
| 39 [56] | 2014 | 50 | M | M. iliopsoas, brain, lung, | Smoking and other drug abuse | TMP/SMX, Imi, Mox | 12 months | survived |
| mediastinal lymph nodes | ||||||||
| 40 [64] | 2015 | 70 | M | Brain abscesses | Multiple Myeloma under chemotherapy | TMP/SMX, Mer, Cip | 12 months | survived |
| 41 [65] | 2016 | 50 | M | Brain abscesses | Smoking and other drug abuse | TMP/SMX, Imi, Line, Mox | 12 months | survived |
| 42 [66] | 2016 | 80 | F | Brain and lung abscess | Immunocompetent | Surgical resection, TMP/SMX, Cef | 9 months | survived |
| 43 [66] | 2016 | 50 | M | Spinal cord, lung | Alcohol abuse | Surgical resection, TMP/SMX, Mer, Cef | 9 months | survived |
| 44 [66] | 2016 | 59 | M | Brain and lung abscess | Immunocompetent | TMP/SMX, Mer | 12 months | survived |
| 45 [67] | 2016 | 54 | M | Brain abscess | Immunocompetent | Cef, Met, Mer, Line, Imi, Van, Rif, TMP/SMX | 21 weeks | survived |
| 46 [3] | 2018 | 61 | M | Brain abscess | Myasthenia gravis, corticosteroid therapy |
TMP/SMX, Cef, Met, Line, Levo | 11 months | survived |
| 47 [2] | 2018 | 66 | F | Renal abscess | Post Lung Transplantation | TMP/SMX, Imi | 9–12 months | survived |
| 48 [68] | 2018 | 42 | M | Lung empyema | Suspected silicosis | TMP/SMX | NR | survived |
| 49 [4] | 2019 | 52 | F | Brain abscess | Immunocompetent | Surgical resection, Cef, TMP/SMX, Levo | 13 months | survived |
| 50 [present report] | 81 | M | Abscess in right adrenal loge | B-Cell Lymphoma, Hypogammaglobulinemia |
Surgical resection, A/clav, TMP/SMX, Amk, Cef, Mino, Cip | 6 months | survived |
Abbreviations: Amk = amikacin; Amp = ampicillin; A/clav = amoxicillin + clavulanic acid; BAL = bronchoalveolar lavage; Cef = ceftriaxone; Cip = ciprofloxacin; Imi = imipenem; Levo = levofloxacin; Line = linezolid; Mer = meropenem; Met = metronidazol; Mino = minocycline; Mox = moxifloxacin; NR = not reported; Rif = rifampicin; Rox = roxifloxacin; Tica/clav = ticarcillin + clavulanic acid; TMP/SMX = trimethoprim-sulfamethoxazole; Van = vancomycin; * not further specified; ** Year of publication.