Table 1.
Characteristics of all included studies and patients recruited into the meta-analysis for quantitative analysis.
| Author | Publication Year | Country | Study Type (n) | Recruitment Dates | Centres (n) | Total Study Population (n) | Cohorts Undergoing Surgery for Comparison | Total in Quantitative Analysis (n) |
|
|---|---|---|---|---|---|---|---|---|---|
| NAT (n) | US (n) | ||||||||
| Versteijne et al. [44] | 2020 | Netherlands | Trial | 2013–2017 | 16 | 246 | 72 | 92 | 164 |
| Lof et al. [37] | 2019 | Europe | Retrospective | 2007–2015 | Multiple | 1236 | 94 * | 94 ± | 188 |
| Yoshiya et al. [26] | 2019 | Japan | Retrospective | 2008–2018 | 1 | 20 | 11 | 9 | 20 |
| Groot et al. [25] | 2019 | USA | Retrospective | 2007–2015 | 1 | 1188 | 231 | 95 * | 1188 |
| Nagakawa et al. [38] | 2019 | Japan | Prospective | 2011–2013 | 63 | 884 | 223 | 27 * | 500 |
| Nurmi et al. [27] | 2018 | Finland | Retrospective | 2000–2015 | 1 | 225 | 75 | 150 * | 225 |
| Jang et al. [7] | 2018 | Korea | Trial | 2012–2014 | 4 | 40 | 17 | 18 | 35 |
| Chen et al. [8] | 2017 | China | Retrospective | 2004–2013 | Multiple | 196 | 98 | 98 * | 196 |
| Masui et al. [45] | 2016 | Japan | Prospective | 2005–2010 | 1 | 37 | 15 | 19 | 34 |
| Ferrone et al. [43] | 2015 | USA | Retrospective | 2011–2014 | 1 | 127 | 40 | 87 | 127 |
| Fujii et al. [28] | 2015 | Japan | Retrospective | 2002–2014 | 1 | 92 | 18 | 50 | 68 |
| Ishikawa et al. [46] | 2015 | Japan | Retrospective | Until 2011 | 1 | 506 | 112 | 238 | 350 |
| Golcher et al. [47] | 2014 | Germany | Trial | 2003–2009 | 1 | 66 | 33 | 33 | 66 |
| Papavasiliou et al. [41] | 2014 | USA | Retrospective | 1990–2009 | 1 | 309 | 108 | 201 | 309 |
| Cho et al. [48] | 2013 | Korea | Retrospective | 2002–2011 | 1 | 51 | 30 | 21 | 51 |
| Jiang et al. [40] | 2013 | China | Retrospective | 2004–2010 | 1 | 232 | 11 β | 120 | 232 |
| Kang et al. [6] | 2012 | Korea | Retrospective | 1999–2010 | 1 | 136 | 32 | 104 | 136 |
| Tajima et al. [49] | 2012 | Japan | Retrospective | 2006–2009 | 1 | 34 | 13 | 21 | 34 |
| Barugola et al. [29] | 2012 | Italy | Retrospective | 2001–2008 | 1 | 403 | 41 | 362 | 403 |
| Katz et al. [50] | 2012 | USA | Retrospective | 2004–2008 | 1 | 147 | 147 | 47 | 194 |
| Barbier et al. [51] | 2011 | France | Retrospective | 1997–2006 | 1 | 173 | 38 | 67 | 105 |
| Sahora et al. [39] | 2011 | Asutria | Retrospective | 2003–2006 | 1 | 106 | 13 | 73 ¥ | 86 |
| Greer et al. [52] | 2008 | Lebanon | Retrospective | 1993–2005 | 1 | 102 | 42 | 41 € | 83 |
| Massucco et al. [42] | 2006 | Italy | Retrospective | 1999–2003 | 1 | 72 | 8 | 44 | 52 |
| Moutardier et al. [53] | 2004 | France | Retrospective | 1997–2002 | 1 | 87 | 23 | 17 | 40 |
| Pingpank et al. [54] | 2001 | USA | Retrospective | 1987–2000 | 1 | 100 | 53 | 47 | 100 |
NAT Neoadjuvant therapy; US Upfront surgery; * Propensity score matched data; € Did not include operation alone as specific outcomes were not reported for this; ± Historical cohort; ¥ Unpublished cohort; β Included both neoadjuvant chemotherapy (n = 81, 72%)and neoadjuvant radiotherapy alone (n = 31, 28%) as outcomes were reported for overall NAT cohort.