Table 1.
MicroRNAs that affect DNA damage response and homologous recombination repair downregulated after irradiation.
| miRNAs | Target Proteins | Studied Material and IR Dose |
Predicted Consequences for Cells | References |
|---|---|---|---|---|
| miR-155, miR-375 |
RAD51 p53 | Thirty-two male FVB/NJ mice, 12 weeks old/liver tissue Dose: 28 mGy |
- | [116,132,133] |
| miR-34a | c-Myc | Human colorectal cancer cells HCT116 p53-/- Doses: 2; 4; 8 Gy |
MiR-34a is a critical mediator of p53 function. | [134,135] |
| c-Myc | Human non-small-cell lung carcinoma (NSCLC) H460 Doses: 1; 2; 5 Gy |
Senescence-promoting effect. | ||
| miR-24, miR-103 & miR-107, miR-106a, miR-155 |
H2AX, RAD51 ATM RAD51 |
Human B lymphoblastic cell line IM9 Dose:1 Gy |
MiR-34a may be involved in the cell cycle response and apoptosis pathway in association with p53. |
[26,64,108,133,136] |
| miR-24, miR-26b, miR-125b, miR-100 |
H2AX ATM p53 ATM |
Normal human fibroblasts AG01522 Dose: 10 Gy |
Regulation of cellular response following irradiation. | [64,104,106,137,138] |
| miR-203 | ATM | Normal thyroid cells Doses: 1; 10 Gy |
MiR-203 dysregulation is associated with radiation exposure and may be unique for thyroid cells. | [139,140] |
| miR-504 | p53 | Human head and neck epithelial malignancy, nasopharyngeal carcinoma (NPC), radio-resistant cell lines CNE2-IR and HK1-IR Doses: 2; 4; 6 Gy |
Induction of radioresistance by down-regulating the expression of NRF1 and disturbing mitochondrial respiratory function. | [117,141] |