Table 1.

Identification of Mutations of Epidermal growth factor receptor (EGFR) Families in Cholangiocarcinoma.

Protein	Cancer Type	Protein Change	Clinical Implications	Mutation Type	Refs
EGFR	ICC	K745_E749 del	Oncogenic	In-F del	[102]
	ECC	E746_A750 del	Oncogenic	In-F del	[102]
	ICC	K575R	Oncogenic	Missense	[103]
	ICC	E872K	Oncogenic	Missense	[103]
	ICC	T790M	Oncogenic	Missense	[103]
	ECC	C775Y	Oncogenic	Missense	[103]
	ECC	G882S	Oncogenic	Missense	[103]
	ECC	V843I	Oncogenic	Missense	[103]
	ECC	L858	Oncogenic	Missense	[103]
	GBC	A864T	Oncogenic	Missense	[103]
	CC	E804K	Oncogenic	Missense	[104]
	ICC	G719S	Oncogenic	Missense	[105]
	ICC	E709K	Oncogenic	Missense	[106]
	ICC	L747_P753 del S ins	Unknown	In-F del	[106]
	ICC	V786M	Oncogenic	Missense	[106]
	CC	G719X	Unknown	Missense	[107]
	CC	S768I	Oncogenic	Missense	[107]
	CC	L861Q	Oncogenic	Missense	[107]
	ICC	T783I	Oncogenic	Missense	[108]
	ICC	S784F	Oncogenic	Missense	[108]
	ICC, ECC	D837N	Oncogenic	Missense	[108]
	ECC	D800G	Oncogenic	Missense	[108]
	ECC	C818R	Oncogenic	Missense	[108]
	ECC	V819M	Oncogenic	Missense	[108]
	ECC	Q820R	Oncogenic	Missense	[108]
	ECC	V851I	Oncogenic	Missense	[108]
	ECC	G873E	Oncogenic	Missense	[108]
	ECC	G874D	Oncogenic	Missense	[108]
	BTC	L443Q	Unknown	Missense	[109]
	BTC	S464P	Oncogenic	Missense	[109]
	BTC	K467*	Unknown	Missense	[109]
	BTC	N468D	Unknown	Missense	[109]
	BTC	G482E	Unknown	Missense	[109]
	BTC	G482R	Unknown	Missense	[109]
	BTC	L469S	Unknown	Missense	[109]
	BTC	L707S	Oncogenic	Missense	[109]
	ECC	E114K	Oncogenic	Missense	[110,111]
	ICC	Y1069C	Oncogenic	Missense	[110,111]
	ICC	I425L	Oncogenic	Missense	[110,111]
	ICC	C818F	Likely oncogenic	Missense	[110,111]
	ICC	R669Q	Oncogenic	Missense	[110,111]
	ICC	V524S	Likely oncogenic	Missense	[110,111]
	GBC	G203R	Oncogenic	Missense	[110,111]
	ICC	R427H	Oncogenic	Missense	[112]
	ICC	R324L	Oncogenic	Missense	[112]
ERBB2	ICC	L755P/S	Oncogenic	Missense	[111]
	ICC	S310F	Oncogenic	Missense	[111,113]
	ICC	L994V	Unknown	Missense	[111]
	GBC, ICC	V842I	Oncogenic	Missense	[111,112]
	GBC, ECC	S310Y	Oncogenic	Missense	[111,112]
	GBC, ECC	G292R	Oncogenic	Missense	[111,112]
	GBC	E265K	Oncogenic	Missense	[111]
	GBC	L1098M	Unknown	Missense	[111]
	ICC	L869R	Oncogenic	Missense	[112]
	ECC	G660D	Oncogenic	Missense	[112]
	ICC	R897W	Oncogenic	Missense	[112]
	ECC	D769H	Oncogenic	Missense	[112]
	ICC, ECC	R678Q	Oncogenic	Missense	[112]
	ECC	T862A	Oncogenic	Missense	[112]
	ICC	S653C	Oncogenic	Missense	[112]
	ECC	G776V	Oncogenic	Missense	[112]
ERBB3	ECC	V104M	Oncogenic	Missense	[110,111]
	ECC	A232V	Oncogenic	Missense	[110,111]
	ECC	G582W	Oncogenic	Missense	[110,111]
	GBC, ICC	G284R	Oncogenic	Missense	[110,111]
	GBC	V104L	Oncogenic	Missense	[110,111]
	GBC, ICC	D297Y	Oncogenic	Missense	[110,111]
	GBC	T355I	Oncogenic	Missense	[110,111]
	GBC	V1035D	Unknown	Missense	[110,111]
	GBC	R444Q	Oncogenic	Missense	[110,111]
	GBC	V586M	Unknown	Missense	[110,111]
	GBC	G994D	Unknown	Missense	[110,111]
	ICC	E928G	Oncogenic	Missense	[110,111]
	ICC	G508R	Oncogenic	Missense	[110,111]
	ICC	A1252S	Unknown	Missense	[110,111]
	ICC	D581N	Unknown	Missense	[110,111]
	ICC	N222Tfs*47	Unknown	FS del	[110,111]
	ICC	E230Dfs*39	Unknown	FS del	[110,111]
	ICC	D73Tfs*11	Unknown	FS del	[110,111]
	ICC	D297Ifs*16	Unknown	FS del	[110,111]
ERBB4	ICC	R103C	Oncogenic	Missense	[110,111]
	ICC	I68N	Oncogenic	Missense	[110,111]
	ICC	L432M	Oncogenic	Missense	[110,111]
	ICC	S602C	Unknown	Missense	[110,111]
	ICC	P1158H	Unknown	Missense	[110,111]
	ICC	S602C	Unknown	Missense	[110,111]
	ICC	S1286Lfs*5	Unknown	FS del	[110,111]
	ICC	F356Sfs*2	Unknown	FS del	[110,111]
	GBC	T475A	Unknown	Missense	[110,111]
	ECC	Q1126K	Unknown	Missense	[112]
	ECC	E835D	Unknown	Missense	[112]
	ECC	F689L	Unknown	Missense	[112]
	ECC	K682N	Oncogenic	Missense	[112]
	ECC	P1092S	Unknown	Missense	[112]
	ECC	R106C	Oncogenic	Missense	[112]
	ECC	S522L	Oncogenic	Missense	[112]
	ECC	S79Y	Oncogenic	Missense	[112]
	ICC	C580*	Oncogenic	Nonsense	[112]
	ICC	D376Y	Unknown	Missense	[112]
	ICC	D960G	Oncogenic	Missense	[112]
	ICC	Q1270K	Oncogenic	Missense	[112]
	ICC	R847C	Oncogenic	Missense	[112]
	ICC	R992H	Oncogenic	Missense	[112]
	ICC	Y1066H	Unknown	Missense	[112]
	ICC	Y950H	Unknown	Missense	[112]

CC: Cholangiocarcinoma; BTC: Biliary Tract Cancer; ECC: Extrahepatic Cholangiocarcinoma; ICC: Intrahepatic Cholangiocarcinoma; GBC: Gallbladder Cancer; In-F del: In-Frame Deletion; FS: Del: Frameshift Deletion.