Table 1.
miR-615-3p interacting genes.
| Target Gene | Description | Gene Action or Effect | Cell Line | Interaction | Effect | Ref. |
|---|---|---|---|---|---|---|
| LCoR | Ligand-dependent nuclear receptor corepressor | Suppress PPARδ | THP-1 cells/splenic macrophages | At the 3’UTR of LCoR, located at the 193 bp downstream of the stop codon | Downregulated | [13] |
| CHOP | C/EBP homologous protein | A proapoptotic transcription factor | Mouse hepatocytes/hepatoma cell line | A single predicted binding site in the 3´UTR, located at 195 bp | Upregulated | [14] |
| FOXO1 | Forkhead box protein O1 | A transcription factor regulating insulin signaling pathway, and played roles in adipogenesis, gluconeogenesis and glycogenolysis | hBMSCs/hFOB1.19 human osteoblast cell line | n.d. | Downregulated | [15] |
| GDF5 | Growth/ differentiation factor 5 |
A member of the TGF-β superfamily and closely related to the bone morphogenetic proteins (BMPs) | hBMSCs/hFOB1.19 human osteoblast cell line | n.d. | Downregulated | [15] |
| OCLN | Occludin | Major component of tight junction | MSCs/ATII cells | n.d. | Downregulated | [16] |
| CK18 | Cytokeratin 18 | Component of cytoskeleton intermediate filaments | MSCs/ATII cells | n.d. | Downregulated | [16] |
| PICK1 | Protein interacting with C kinase 1 | Regulation of traffic between surface receptors | Human breast cancer cell lines | Targeting the 3′-UTR | Downregulated | [17] |
| IGF2 | Insulin-like growth factor 2 | Growth factor has growth-regulating, insulin-like and mitogenic activities | MKN28, MKN45, SGC7901 and GES-1 cell lines; NSCLC cell lines. | Directly binds to the 3´-UTR | Downregulated | [18,19] |
| hTERT | Telomerase reverse transcriptase | A catalytic subunit of the enzyme telomerase | 56 different NCI-60 cell lines | Targeting its 3′UTR | Downregulated | [20] |
| CELF2 | CUGBP Elav-like family member 2 | A tumor suppressor RNA-binding protein implicated in the regulation of several post-transcriptional events | MKN28, MKN45, SGC7901 and GES-1 cell lines | n.d. | Downregulated | [11] |
| HMGB3 | High mobility group box 3 | Multifunctional protein with various roles in different cellular compartments | Human normal bronchial epithelial cell line 16HBE/NSCLC cell lines (A549 and H1299) | n.d. | Downregulated | [21] |
| JunB | JunB proto-oncogene, AP-1 transcription factor subunit | Transcription factor involved in regulating gene activity following the primary growth factor response | Human ESCC cell lines (Eca-109, TE-1 and KY-SE) and human normal esophageal cell line | Downregulated by NORAD | Upregulated | [22] |
| AP-1 | Transcription factor subunit | Involved in several cellular processes (cell growth, differentiation and apoptosis) | Human ESCC cell lines (Eca-109, TE-1, and KY-SE) and Human normal esophageal cell line | Downregulated by NORAD | Upregulated | [22] |
| Ywhag | 14-3-3-δ, protein kinase C inhibitor protein 1 | An abundant, cytosolic and brain-specific protein, which mediates signal transduction | Mice cerebral anterior cortex | Downregulated | [23] | |
| LINGO-1 | LRR and Ig domain containing NOGO receptor interacting protein 1 | Transmembrane protein selectively expressed in neurons and oligodendrocytes in CNS and the spinal cord, mediating axon growth | NSCs fetal brain 14th E.D. | Bind with the target sites (GGACCCC) in the 3′-UTR located in 202-223bp | Downregulated | [24] |
n.d., not defined; PPARδ, peroxisome proliferator-activated receptor gamma; TGF-β, transforming growth factor beta; CNS, central nervous system; NSC, neural stem cells.