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. 2020 Jul 9;12(7):1852. doi: 10.3390/cancers12071852

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Potent anti-tumor effects of miRNA therapy through various delivery methods. (a) Local liposome-miR-7-plasmid treatment of xenograft mice [73]. (b) In vivo tumorigenicity assessment of polyurethane-short branch polyethylenimine (PU-PEI)-mediated miR-145 delivery to patient-derived Glioblastoma (GMB) cells [78]. (c) Tumor sizes of xenograft mice after systemic super carbonate apatite (sCA)-mediated miR-4711-5p delivery [84]. (d) Inhibition of metastatic tumor growth in bone tissues by the atelocollagen-mediated miRNA treatment [93]. (e) Inhibition of breast cancer development in vivo using GE11-positive exosomes containing let-7a [91].