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. 2020 Jun 27;9(7):1568. doi: 10.3390/cells9071568

Figure 3.

Figure 3

Positive and negative factors affecting eukaryotic translation initiation. (A) Inactivity of M phase-promoting factor (MPF) during interphase; lack of nutrients or stress lead to dephosphorylation of eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) which results in formation of translational repressory complex on mRNA. (B) Active MPF, availability of nutrients or growth factors lead to hyperphosphorylation of 4E-BP1 resulting in dissociation from eIF4E and promoting formation of 4F complex and translation of specific mRNAs (e.g., mRNAs containing 5′UTR TOP motive).