Table 3.
The most impacted molecular function, biological processes and cellular components in muscle proteomic analyses identified in rats with Walker tumour-bearing fed/not fed a leucine-rich diet and euthanatised at 21st day of the experiment.
| # Pathway ID | Molecular Function Pathway Description | Gene Count | FDR |
| GO.0003824 | Catalytic activity | 35 | 1.79 × 10−19 |
| GO.0016491 | Oxidoreductase activity | 17 | 2.23 × 10−14 |
| GO.0015078 | Hydrogen ion transmembrane transporter activity | 10 | 1.50 × 10−13 |
| GO.0043167 | Ion binding | 29 | 1.33 × 10−12 |
| GO.0048037 | Cofactor binding | 11 | 1.09 × 10−10 |
| GO.0009055 | Electron carrier activity | 7 | 1.71 × 10−09 |
| GO.0050662 | Coenzyme binding | 9 | 6.65 × 10−09 |
| GO.0003674 | Molecular function | 33 | 1.48 × 10−08 |
| GO.0046872 | Metal ion binding | 20 | 1.48 × 10−08 |
| GO.0005215 | Transporter activity | 14 | 2.68 × 10−08 |
| # Pathway ID | Biological Process Pathway Description | Gene Count | FDR |
| GO.0006091 | Generation of precursor metabolites and energy | 20 | 6.99 × 10−29 |
| GO.0044710 | Single-organism metabolic process | 34 | 3.18 × 10−23 |
| GO.0055114 | Oxidation-reduction process | 24 | 3.18 × 10−23 |
| GO.0019752 | Carboxylic acid metabolic process | 21 | 1.59 × 10−19 |
| GO.0072350 | Tricarboxylic acid metabolic process | 10 | 1.54 × 10−17 |
| GO.0044281 | Small molecule metabolic process | 23 | 2.07 × 10−17 |
| GO.0006099 | Tricarboxylic acid cycle | 9 | 3.87 × 10−16 |
| GO.0045333 | Cellular respiration | 11 | 8.45 × 10−16 |
| GO.0046496 | Nicotinamide nucleotide metabolic process | 11 | 8.45 × 10−16 |
| GO.0015980 | Energy derivation by oxidation of organic compounds | 12 | 1.31 × 10−15 |
| GO.0006732 | Coenzyme metabolic process | 13 | 2.82 × 10−15 |
| # Pathway ID | Cellular Component Pathway Description | Gene Count | FDR |
| GO.0005739 | Mitochondrion | 32 | 3.66 × 10−31 |
| GO.0031966 | Mitochondrial membrane | 23 | 1.17 × 10−26 |
| GO.0005740 | Mitochondrial envelope | 23 | 3.64 × 10−26 |
| GO.0044444 | Cytoplasmic part | 42 | 1.17 × 10−25 |
| GO.0005743 | Mitochondrial inner membrane | 19 | 1.29 × 10−23 |
| GO.0044429 | Mitochondrial part | 22 | 1.00 × 10−22 |
| GO.0043209 | Myelin sheath | 14 | 2.79 × 10−19 |
| GO.0005737 | Cytoplasm | 39 | 1.46 × 10−16 |
| GO.0043234 | Protein complex | 26 | 5.62 × 10−15 |
| GO.0070062 | Extracellular exosome | 20 | 6.93 × 10−15 |
| GO.0031090 | Organelle membrane | 24 | 1.04 × 10−14 |
| GO.0031988 | Membrane-bounded vesicle | 22 | 9.29 × 10−14 |
False discovery rate (FDR). Statistical analysis described in Methods, showing the significant value for p < 0.05.