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. 2020 Jul 17;9(7):2276. doi: 10.3390/jcm9072276

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in chromatin arrangement via circular chromosome conformation capture (4c) in K562 and HEL92.1.7 cell lines with imatinib treatment. Libraries were generated using DpnII and Csp61 in subsequent restriction enzyme digestions using primers for the HBG2 promoter (Forward: CAAAGCACCTGGATGATC, Reverse: TTGTCTCTAGCTCCAGTGAG). (A) Changes in chromosomal cis-interactions with HBG2 promoter on chromosome 11 with imatinib treatment in K562 cells; (B) Changes in chromosomal cis-interactions with HBG2 promoter on chromosome 11 with imatinib treatment in HEL92.1.7 cells.