Table 1.
Top 20 FDA-approved drugs that positively modulate HbF in K562 s.
| Drug Name | Fold Change | Indication |
|---|---|---|
| Daunorubicin Hydrochloride | 4.55 | Acute Myeloid Leukemia |
| Albendazole | 2.86 | Anthelmintic |
| Chloroxine | 2.76 | Seborrheic Dermatitis |
| Raltitrexed | 2.62 | Colorectal Cancer |
| Epirubicin Hydrochloride | 2.58 | Breast Cancer |
| Floxuridine | 2.50 | Hepatic Cancer |
| Pindolol | 2.50 | Hypertension |
| Methylprednisolone | 2.32 | Rheumatoid Arthritis |
| Fexofenadine Hydrochloride | 2.28 | Seasonal Allergic Rhinitis |
| 6-Azauridine | 2.25 | Psoriasis |
| Pyrimethamine | 2.23 | Malarial Infection |
| Mafenide Acetate | 2.11 | Bacterial Infection |
| Prednisolone | 2.09 | Congenital Adrenal Hyperplasia |
| Ribavirin | 2.02 | Chronic Hepatitis C |
| Quinidine Hydrochloride | 1.99 | Cardiac Dysrhythmia |
| Ebselen | 1.95 | Type 2 Diabetes Mellitus * |
| Tegaserod Maleate | 1.93 | Irritable Bowel Syndrome |
| Delta1-Hydrocortisone 21-hemisuccinate Sodium | 1.90 | Corticosteroid-responsive Dematoses |
| Enalapril Maleate | 1.81 | Congestive Heart Failure |
| Granisetron Hydrochloride | 1.75 | Nausea |
* investigational small molecule