Table 2.
Compositional change in the bacterial set between sampling time points.
| Visit 2 vs. 3 | Genus | Placebo-Visit 2 | Placebo-Visit 3 | Ratio | Probiotics-Visit 2 | Probiotics-Visit 3 | Ratio |
| Set I bacteria | Bifidobacterium | 4.388% | 2.810% | −36.0% | 3.638% | 3.225% | −11.3% |
| Akkermansia | 0.859% | 0.229% | −73.3% | 1.178% | 1.338% | 13.5% | |
| Parabacteroides | 1.914% | 0.561% | −70.7% | 0.397% | 0.507% | 27.7% | |
| Veillonella | 0.448% | 0.176% | −60.8% | 0.226% | 1.192% | 428.3% | |
| Lactobacillus | 2.231% | 1.084% | −51.4% | 0.669% | 0.526% | −21.3% | |
| Erysipelatoclostridium | 0.419% | 0.085% | −79.7% | 0.077% | 0.072% | −6.0% | |
| Set II bacteria | Prevotella | 7.368% | 9.650% | 31.0% | 10.286% | 15.469% | 50.4% |
| Alloprevotella | 0.687% | 0.822% | 19.6% | 1.053% | 1.368% | 29.9% | |
| Fusobacterium | 0.174% | 0.215% | 23.3% | 1.176% | 0.041% | −96.6% | |
| Porphyromonas | 0.713% | 1.050% | 47.3% | 0.465% | 0.012% | −97.4% | |
| Visit 3 vs. 6 | Genus | Placebo-Visit 3 | Placebo-Visit 6 | Ratio | Probiotics-Visit 3 | Probiotics-Visit 6 | Ratio |
| Set I bacteria | Bifidobacterium | 2.810% | 6.873% | * 144.6% | 3.225% | 9.484% | ** 194.1% |
| Akkermansia | 0.229% | 2.224% | 870.1% | 1.338% | 4.164% | 211.2% | |
| Parabacteroides | 0.561% | 3.715% | ** 562.6% | 0.507% | 5.836% | * 1051.3% | |
| Veillonella | 0.176% | 2.445% | * 1291.6% | 1.192% | 2.483% | 108.2% | |
| Lactobacillus | 1.084% | 1.195% | 10.2% | 0.526% | 0.875% | 66.2% | |
| Erysipelatoclostridium | 0.085% | 0.541% | * 535.7% | 0.072% | 0.356% | * 393.4% | |
| Set II bacteria | Prevotella | 9.650% | 2.214% | * −77.1% | 15.469% | 2.292% | *** −85.2% |
| Alloprevotella | 0.822% | 0.097% | −88.2% | 1.368% | 0.004% | ** −99.7% | |
| Fusobacterium | 0.215% | 0.917% | 326.3% | 0.041% | 0.227% | 459.2% | |
| Porphyromonas | 1.050% | 0.287% | −72.7% | 0.012% | 0.001% | * −91.0% | |
| Visit 6 vs. 7 | Genus | Placebo-Visit 6 | Placebo-Visit 7 | Ratio | Probiotics-Visit 6 | Probiotics-Visit 7 | Ratio |
| Set I bacteria | Bifidobacterium | 6.873% | 7.339% | 6.8% | 9.484% | 9.961% | 5.0% |
| Akkermansia | 2.224% | 7.041% | 216.7% | 4.164% | 9.256% | 122.3% | |
| Parabacteroides | 3.715% | 4.203% | 13.1% | 5.836% | 3.847% | −34.1% | |
| Veillonella | 2.445% | 0.660% | −73.0% | 2.483% | 2.786% | 12.2% | |
| Lactobacillus | 1.195% | 0.917% | −23.3% | 0.875% | 1.239% | 41.6% | |
| Erysipelatoclostridium | 0.541% | 0.666% | 23.2% | 0.356% | 0.487% | 37.1% | |
| Set II bacteria | Prevotella | 2.214% | 2.562% | 15.7% | 2.292% | 3.287% | 43.4% |
| Alloprevotella | 0.097% | 0.091% | −5.9% | 0.004% | 0.004% | −7.9% | |
| Fusobacterium | 0.917% | 0.620% | −32.4% | 0.227% | 0.237% | 4.4% | |
| Porphyromonas | 0.287% | 0.302% | 5.3% | 0.001% | 0.000% | −79.3% | |
| Visit 2 vs. 7 | Genus | Placebo-Visit 2 | Placebo-Visit 7 | Ratio | Probiotics-Visit 2 | Probiotics-Visit 7 | Ratio |
| Set I bacteria | Bifidobacterium | 4.388% | 7.339% | 67.2% | 3.638% | 9.961% | * 173.8% |
| Akkermansia | 0.859% | 7.041% | 720.1% | 1.178% | 9.256% | * 685.4% | |
| Parabacteroides | 1.914% | 4.203% | 119.6% | 0.397% | 3.847% | * 869.3% | |
| Veillonella | 0.448% | 0.660% | 47.4% | 0.226% | 2.786% | * 1134.4% | |
| Lactobacillus | 2.231% | 0.917% | −58.9% | 0.669% | 1.239% | 85.1% | |
| Erysipelatoclostridium | 0.419% | 0.666% | 58.9% | 0.077% | 0.487% | 535.9% | |
| Set II bacteria | Prevotella | 7.368% | 2.562% | −65.2% | 10.286% | 3.287% | * −68.0% |
| Alloprevotella | 0.687% | 0.091% | −86.7% | 1.053% | 0.004% | * −99.7% | |
| Fusobacterium | 0.174% | 0.620% | 255.5% | 1.176% | 0.237% | −79.9% | |
| Porphyromonas | 0.713% | 0.302% | −57.6% | 0.465% | 0.000% | −100.0% |
* p-value <0.05; ** p-value; *** p-value <0.001.