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EC50 values of s2R ligands in control, TMEM97 KO, PGRMC1 KO and double KO cell lines.
| Ligand | Control (µM) Mean ± SD |
TMEM97 KO (µM) Mean ± SD |
PGRMC1 KO (µM) Mean ± SD |
Double KO (µM) Mean ± SD |
|---|---|---|---|---|
| Siramesine | 12.1 ± 1.7 | 10.3 ± 1.49 | 10.7 ± 0.7 | 10.0 ± 1.3 |
| SW43 | 33.7 ± 8.6 | 30.4 ± 3.4 | 33.2 ± 1.6 | 32.8 ± 3.8 |
| PB28 | 58.2 ± 5.9 | 59.8 ± 10.7 | 59.4 ± 8.0 | 57.4 ± 6.9 |
| RHM-4 | >200 | >200 | >200 | >200 |
| ISO-1 | >200 | >200 | >200 | >200 |
