Table 2.

Gut microbiota alterations in AD mice.

AD Model	Control	Age	Alterations of Abundance	References
APP/PS1	WT	3, 6 and 8 months	At 3, 6 and 8 months: ↑ Helicobacteraceae, Desulfovibrionaceae, Odoribacter, Helicobacter; ↓ Prevotella. At 6 and 8 months: ↑Coriobacteriaceae; ↓Ruminococcus.	Shen et al. 2017
APP/PS1	WT	6 and 24 months	At 6 and 24 months: ↑Proteobacteria, Sutterella; ↓Rikenellaceae. At 24 months: ↑Erysilopelotrichaceae.	Bauerl et al. 2018
5xFAD	WT	9 weeks	↑Firmicutes, Clostridium leptum group; ↓Bacteroidetes.	Brandscheid C. et al. 2017
SAMP8	SAMR1	7 months	↓Deferribacteres, Deferribacteres, Deltaproteobacteria, Deferribacterales, Desulfovibrionales, Mollicutes RF9, Clostridiales vadinBB60 group, Desulfovibrionaceae, Christensenellaceae, Family XIII, Deferribacteraceae, Ruminococcaceae, Mucispirillum, Serratia, Family XIII AD3011 group, Christensenellaceae R-7 group, Subdoligranulum, Desulfovibrio, Ruminiclostridium 9, Coprococcus 1, Ruminococcaceae UCG 004, Lachnospiraceae NK4A136 group, Lachnospiraceae oscillibacter	Zhan et al. 2018
SAMP8	SAMR1	8 months	↑norank f Lachnospiraceae, Alistipes, Odoribacter, unclassified f Lachnospiraceae, Akkermansia in SAMP8; ↑ norank_f Bacteroidales S24-7 group, Prevotella 9, Parasutterella, Butyrivibrio in SAMR1.	Peng et al. 2018

Abbreviations SAMP8: senescence accelerated mouse prone 8 mice; SAMR1: senescence-accelerated mouse resistant 1 mice; APP/PS1: APPswe/PS1dE9 mice; 5xFAD: 5xFAD (APP K670N, M671L, I716V, PS1 M146L, L286V) mice; WT: wild type; ↑, increased abundance; ↓, decreased abundance.