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. 2020 Jul 16;12(7):1922. doi: 10.3390/cancers12071922

Figure 2.

Figure 2

CN133 and CN147 have stronger anti-tumoral activity than SAHA and are more cytotoxic in tumor cells than in non-transformed cells. Cell viability assay in EPP (a) or EPV (b) cell lines with either vehicle (DMSO) or with the indicated HDACi at 500 nM, 1 μM or 10 μM for 72 h. Cell viability was evaluated using Alamar Blue reagent. Graph represents the average of three independent experiments. (c,d) Cell viability assays in EPP, EPV or neuronal progenitors (NP) treated with vehicle (DMSO) or the indicated doses of CN133 (c) or CN147 (d) for 72 h. Cell viability was evaluated using Alamar Blue reagent. Each graph represents the average of three independent experiments (n = 6/each experiment) ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001.