Table 2.
Change of the relationship between SUA and parameters of vascular remodeling following adjustment for endothelial function and nitric oxide (NO) availability.
| Unadjusted | Adjusted for Endothelial Function | Adjusted for NO Availability | ||||
|---|---|---|---|---|---|---|
| Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | |
| Dependent variable: M/L ratio | ||||||
| SUA | −0.354 (−0.557, −0.152) |
<0.001 | −0.017 (−0.034, 0.067) |
0.511 | 0.012 (−0.04, 0.063) |
0.647 |
| Dependent variable: MCSA | ||||||
| SUA | −1.59 (−2.22, −0.952) |
<0.001 | −0.015 (−0.097, 0.067) |
0.716 | −0.027 (−0.113, 0.06) |
0.541 |
Abbreviations: M/L ratio = media-to-lumen ratio; MCSA = media cross-sectional area; SUA = serum uric acid. Fractional polynomials were used to model the association of continuous uric acid with M/L ratio and MCSA. Coefficients correspond to first degree polynomials or the linear term of second-degree polynomials. M/L ratio and MCSA were used in the natural log transformed scale. Adjusted models additionally controlled for Heart Score.