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Concentrations of the Calibration Standard (CAL) and Quality Control (QC) Samples of Osimertinib in Solution and in Spiked Plasma.
| Calibration Point | Concentration in Solution (ng/mL) | Virtual Concentration in Plasma (ng/mL) |
|---|---|---|
| CAL1000 | 2000 | 1000 |
| CAL500 | 1000 | 500 |
| CAL200 | 400 | 200 |
| CAL100 | 200 | 100 |
| CAL50 | 100 | 50 |
| CAL20 | 40 | 20 |
| CAL10 | 20 | 10 |
| CAL5 | 10 | 5 |
| CAL0 | 0 | 0 |
| Blind value (BV) | 0 | 0 |
| High QC (HQC) | 1600 | 800 |
| Middle QC (MQC) | 800 | 400 |
| Low QC (LQC) | 30 | 15 |
| Lower limit of quantification (LLOQ) | 10 | 5 |
