Table 4.

Management of hyperthyroidism induced by immune checkpoint inhibitors.

CTCAE Grade	Management	Treatment of Adverse Event
Grade 1	Continue ICI treatment	Continue to monitor TSH and FT4 levels until hyperthyroidism disappears
Grade 2	Stop ICI treatment until the symptoms ameliorate or test values become normal After amelioration of symptoms, resume administration of ICI	Consult an endocrinologist Perform a thyroid function test every 2–3 weeks If the thyroid poisoning does not resolve after 6–8 weeks, Graves’ disease is differentiated
Grade 3 or 4	Same as above	Consult an endocrinologist Start administration of β-blocker Conduct clinical tests every 1–3 weeks In case of thyroid crisis, treat the patient in the intensive care unit

CTCAE, Common Terminology Criteria for Adverse Events; ICI, immune checkpoint inhibitor; TSH, thyroid-stimulating hormone; FT4, free T4.