Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Targeting telomeric components and telomerase as a potential therapeutic approach against human malignancies. TRF1 inhibitors such as ETP-47228, ETP-47037 block the TRF1 binding at the site of telomeres and prevent the formation of a shelterin complex to eradicate cancer cells. Several classes of telomerase inhibitors including nucleoside analogs, oligonucleotides, nonnucleoside, nutraceuticals, Isothiazolone derivatives, G4-DNA stabilizer.
