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. 2020 Jun 29;9(7):2034. doi: 10.3390/jcm9072034

Figure 1.

Figure 1

Association of CFH gene polymorphism with age-related macular degeneration (AMD) and pachychoroid. A single nucleotide polymorphism of I62V (rs800292) in CFH has a significant association with the development of AMD. G allele is a risk allele for drusen and AMD, while A allele is a protective allele for drusen and AMD (A). I62V in CFH has opposite effects on AMD and pachychoroid. G allele is a risk allele for drusen and AMD but a protective allele for pachychoroid (B). I62V in CFH has similar effects to choroidal neovascularization (CNV) development in AMD and pachychoroid diseases. G allele is a risk allele for CNV development both in pachychoroid diseases and drusen-driven AMD (C).