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Extracellular vesicles (EV)/exosomes (Exo) as drug carriers: endogenous or exogenous loading. Drugs can be loaded into EV/Exo in two ways: (a) endogenous loading exploits EV/Exo-producing cells that are treated with the drug of interest, which is carried into EV/Exo inside the cell and eventually released as EV cargo in the extracellular milieu; (b) exogenous loading is obtained by manipulating isolated purified EV/Exo to carry the desired agent.
