Table 1.

TLDA Profiling Showed the Differential Expression of 20 MiRNAs in the Different Comparisons

	ANOVA	C Versus A + B		D Versus A + B		D Versus C
miRNA	P Value	FC	P Value	FC	P Value	FC	P Value
let-7b-5p	0.022	−16.85	0.021	3.76	0.33	28.76	0.009
miR-100-5p	0.003	−13.21	0.008	4.9	0.06	24.76	0.001
miR-1300	0.003	12.59	0.005	−3.45	0.1	−23.53	0.001
miR-143-3p	< 0.0001	9.93	0.0005	26.41	< 0.0001	2.65	0.08
miR-152-3p	0.01	−5.28	0.1	12.03	0.024	33.68	0.003
miR-16-5p	0.026	−4.94	0.22	16.77	0.035	32.68	0.009
miR-19b-3p	0.019	−2.79	0.1	3.59	0.049	10.03	0.006
miR-203a	0.033	−5.64	0.13	8.95	0.07	30.51	0.011
miR-21-5p	0.011	1.19	0.83	22.15	0.004	18.56	0.013
miR-218-5p	< 0.0001	−1.45	0.27	15.28	< 0.0001	22.3	< 0.0001
miR-223-5p	0.016	−11.65	0.008	1.14	0.85	13.3	0.013
miR-224-5p	0.003	2.46	0.38	36.26	0.001	28.97	0.01
miR-30b-5p	0.039	−26.91	0.017	−1.02	0.98	26.33	0.034
miR-335-5p	0.025	−8.72	0.033	3.09	0.22	26.99	0.009
miR-340-5p	0.031	−2.91	0.25	8.36	0.039	24.38	0.012
miR-361-5p	0.003	4.82	0.26	36.81	0.001	18.78	0.014
miR-452-5p	0.0002	19.17	0.001	33.38	< 0.0001	5.6	0.07
miR-486-3p	0.011	6.06	0.08	32.98	0.004	5.43	0.14
miR-891a-5p	0.002	2.46	0.4	35.38	0.0007	21.01	0.005
miR-99a-5p	0.001	−21.67	0.002	3.82	0.1	32.84	0.0006

The average FC and the P value derived from multiple comparisons for each miRNA are shown. The P value of the ANOVA test between all groups is also shown. Significant P values are highlighted in bold.

FC, fold change.