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. 2020 Jul 3;8(7):995. doi: 10.3390/microorganisms8070995

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Microbial signatures correlated with gut luminal putrescine levels. (A) A diagram showing the arginine metabolism pathway. (B) The levels of putrescine and N-acetylputrescine (C) significantly impacted by neoagarotetraose (NT). (D) Microbial genera that were correlated with gut putrescine concentrations identified using a Random Forest regression model. E: A global balance or microbial signature strongly correlated with gut putrescine concentrations. NC: normal controls; MD: colitis induced by DSS; NT: DSS induced colitis mice supplemented with NT. %IncMSE: Percentage increase in mean squared error. * p < 0.05; *** p < 0.001.