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. 2020 Jul 20;12(7):1969. doi: 10.3390/cancers12071969

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Co-expression of IL-7 reduces the apoptosis of NKG2D-CAR T cells. (a) After NKG2D-CAR and NKG2DIL7-CAR T cells were cocultured with PC-3 tumor cells for 7 days, the cells were stained with Annexin-V/7-AAD and the apoptosis was detected by FACS. The statistical analysis was shown in the right panel. (b) Flow cytometric analysis of Bcl-2 protein expression in CAR T cells 7 days after tumor cell stimulation. (c) The Bcl-2 expression in CD4⁺ and CD8⁺ CAR T cells was detected by FACS 7 days after tumor cell stimulation. ** p < 0.01. Data are representative of 4 donors and have been gated on NKG2D⁺ T cells.