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IL-7 increases CAR T cells with the less differentiated phenotype and inhibits CAR T-cell exhaustion. (a,b) T-cell phenotype based on CD45RA and CCR7 expression in CD4+ (a) and CD8+ (b) CAR T cells was analyzed by FACS after 14 days of culture. (c), Surface expression of PD-1 and Tim-3 on CAR T cells was analyzed by FACS after 7 days of co-culture with tumor cells. * p < 0.05, ** p < 0.01. Data are representative of four T-cell lines.
