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. 2020 Jul 20;8(7):1078. doi: 10.3390/microorganisms8071078

Table 1.

Thresholds proposed in the literature to consider CMV infection to be of significant impact.

Method Number of patients Threshold Reference
IHC
80 UC 0.01 cells/mm2 [82]
114 UC 1 inclusion body in histology,
positive specific IHC staining for CMV in 10–20 fields of colonic biopsies
[55]
13 CD, 18 UC semiquantitative
ranging from 1 to 3 (1=rare, 2=common and easy to find, and 3=numerous cells positive for CMV)
[83]
30 UC, 8 CD semiquantitative
ranging from 1 to 3 (1 = rare, 2 = common and easy to find, and 3 = numerous cells positive for CMV)
[84]
95 UC ≥ 5 IHC positive cells/biopsy [85]
46 UC colectomy was only associated with > 2 positive cells/biopsy [86]
257 UC semiquantitative
low grade (1 to 4 inclusion bodies per section) high grade (at least 5 inclusion bodies per section)
[70]
qPCR
30 UC 10 copies/µg of DNA [87]
42 UC 10 copies/mg of tissue [44]
40 IBD > 1000 copies/100,000 cells [80]
149 UC 5 IU/100,000 cells [81]
92 UC, 9 CD ≥ 316 copies/mg of DNA [64]
75 IBD 10,000 copies/µg of DNA [88]
103 UC, 30 CD > 600 copies/100 000 cells of tissue [45]
47 IBD > 250 copies/mg of tissue [42]

IHC: Immunohistochemistry, qPCR: Quantitative polymerase chain reaction, UC: Ulcerative colitis, CD: Crohn disease, IBD: Inflammatory bowel disease, IU: International unit.