Figure 1.

Summary of the hematopoietic compartments in fruit flies that can be used for leukemia studies. Drosophila larva serves as an efficient in vivo model with its easily accessible hematopoietic compartments and transparent cuticle that allows clear identification of oncogene-induced phenotypes. The adult fly serves in providing a primary efficient read-out for genetic and chemical screening. The larval lymph gland and hematopoietic hubs in the larvae and adult respectively shape a simple mammalian bone marrow that can be exploited in leukemia research. MZ: medullary zone (blue); CZ: cortical zone (orange); PSC: posterior signaling center (purple).