Figure 1.

(A) Alteration of C-terminal amino acids of the apolipoproein A2 (apoA2) isoforms. The theoretical molecular weights of the five isoforms of apoA2 are shown at left. (B) The normal apoA2 isoforms were primarily distributed in healthy controls. However, the hypo-processing pattern, in which apoA2-ATQ/ATQ was predominantly expressed, and the hyper-processing pattern, in which apoA2-AT/AT was predominantly expressed, were detected in patients with pancreatic ductal adenocarcinoma (PDAC) or its risk-conferring diseases. In both the hyper- and hypo-processing patterns, because apoA2-ATQ/ATQ or apoA2-AT/AT was increased, apoA2-ATQ/AT consequently decreased in PDAC [109].