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. 2020 Jul 20;12(7):1972. doi: 10.3390/cancers12071972

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Pinometostat sensitizes primary cells from pediatric AML patients to Sorafenib treatment. (A) Growth curves of primary AML cells pre-treated with Pinometostat before Sorafenib addition (Pinometostat/Sorafenib ratio 1:1). The pre-treatment model consists of 4 or 8 days of treatment with Pinometostat followed by 24 or 48 h treatment with Sorafenib. Combination times are indicated in each panel. (B) Flow cytometry analysis of apoptosis measured by Annexin V-FITC/PI staining in primary AML cells treated with 10 µM of Pinometostat (8 days), Sorafenib (48 h), or combined drugs (8 days + 48 h). Ctr: control cells (DMSO 0.01%). Results of three independent replicates are presented as means ± SD.