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LLT1 is expressed on specific tumor cells such as triple-negative breast cancer (TNBC), prostate cancer, and B-cell non-Hodgkin’s lymphoma (NHL) cells. LLT1 on tumor cells interacts with NKR-P1A on NK cells, sending an inhibitory signal to NK cells which decreases cytolytic function. Cancer cells have also been shown to upregulate LLT1 expression to increase the immune dampening effect.
