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. 2020 Jul 21;12(7):1987. doi: 10.3390/cancers12071987

Figure 1.

Figure 1

Legend. Tumor-associated macrophage (TAM) functions. Upon stimulation by a TLR, microbial substrates, IFNγ and CSF2, M1-TAMs secrete cytokines such as IL6, IL12, IL23 and TNFα and express specific M1 markers like MHCII molecules, CD68, CD80, CD86, iNOS and pSTAT. The adopted phenotype confers proinflammatory/antitumor features to TAMs. Upon stimulation by IL4, IL13, IL10, TGFβ and chemokines, M2-TAMs secrete IL4, IL13, IL10, TGFβ and PGE2. M2- TAMs express CD163, CD204, CD206, VEGF, cMAF, CD200R, macrophage galactose-type lectin (MGL) 1 and MGL2, all markers representative of the M2 phenotype characterized by anti-inflammatory/protumor functions.