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. Author manuscript; available in PMC: 2021 Jul 15.
Published in final edited form as: Brain Res. 2020 Apr 27;1739:146861. doi: 10.1016/j.brainres.2020.146861

Figure 2. Diagnostic performance of digital ELISA measures of brain specific-proteins.

Figure 2.

(A-C) ROC curves depicting the ability of digital ELISA measures of plasma NfL, Tau, and their combination to discriminate between ischemic stroke patients and controls. To assess combined diagnostic performance, ROC curves were generated via k-nn prediction probabilities. The diagnostic cut-off with the highest combined sensitivity and specificity is indicated. (D) Comparison of the areas under ROC curves for digital ELISA measures of plasma NfL, Tau, and their combination. Areas were statistically compared using the DeLong method. 95% confidence intervals associated with all diagnostic statistics are indicated. AUC, area under curve; Pr, probability; *statistically significant.