Table 2.

PDAC related diagnostic aptamers

Name	Target	SELEX method	Positive selection	Negative selection	Oligos	Applications	Model	Ref.
M9–5	Cyclophilin B	Secretome	MiaPaCa-2	HPDE	RNA	biomarker detection	Patients and	[45]
							KPC mice serum	[44]
C14B	AGR2	Protein	AGR2-GST	GST	DNA	probe generation	In vitro	[68]
SQ-2	ALPPL-2	Cell	Panc-1	HPDE	RNA	biomarker detection	In vitro	[38]
			Capan-1			biosensor generation		[39]
BC-15	hnRNP A1	Tissue	PDAC	Adjacent normal tissue	DNA	CTCs detection	Patients serum	[46]
XQ-2d	CD71	Cell	PL45	hTERT-HPNE	DNA	biomarker detection	In vitro	[40]
						Cy-5-labeled fluorescence imaging	Xenograft model Human sections	[93]
PL8	HPAC	Cell	PL45	TOV-21G	DNA	New biomarker detection	In vitro	[41]
Apt.1	CSCs	Cell	HPAC (CRL2119)	HPDE	DNA	CSCs detection;	In vitro	[42]
Apt.146	CSCs	Cell	HPAC (CRL2119)	HPDE	DNA	New biomarker detection	In vitro	[42]
Ap52	MAGE-A3	Peptide	MAGE-A3111–125	None	DNA	Cy-3-labeled fluorescence imaging	In vitro	[49]
P19/P1	HPAC	Cell	PANC-1	Huh7	RNA	Cy-3-labeled fluorescence imaging	Human tumor tissue sections	[55]
AP1153	CCKBR	Peptides	CCKBR peptides	COS-1	DNA	ICG labeled fluorescence imaging	Orthotopic model	[94]
		Cell	PANC-1
M17	MMP14	Cell	293 T-MMP14 cells	293 T cells	DNA	Cy-3-labeled fluorescence imaging	Xenograft model	[51]