Fig. 5.

Knockdown of LINC00152 and block of EGFR have a synergic effect of inhibition in cell proliferation in zebrafish xenograft. a-d Lung cancer cells with NC transfection (a, b) or si-LINC00152 transfection were injected into the PVS of 2-dpf WT zebrafish larvae, and afatinib was bathed in zebrafish culture medium (b, d) or not (a, c). Images were taken by a confocal microscope at 3 dpt. e, f Statistical analysis of the proliferation and invasion with NC or LINC00152 siRNA transfection and afatinib administration or not. ns, not statistically significant, *: p < 0.05. Scale: 100 μm