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Two mechanisms of hepatoblastoma formation. a: Hepatic differentiation is blocked during the embryonic stage, and DNA methylation stays in the early stages of liver differentiation. Incompletely differentiated cells remain in the fetal liver after birth, and abnormal proliferation of the cells causes hepatoblastoma. b: The mutation of exon 3 of CTNNB1 gene in fetal liver cells causes β-Catenin accumulation, and abnormal cell proliferation leads to HB
