Table 1.
Gross examination.
| Animal No. | Dose of talc | 2 weeks time | 4 weeks time | 6 weeks time | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Palpable area of fibrosis | Stiffness of the area | Infection | Wound dehiscence | Palpable area of fibrosis | Stiffness of the area | Infection | Wound dehiscence | Palpable area of fibrosis | Stiffness of the area | Infection | Wound dehiscence | ||
| 1 | 0 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 2 | 0 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No |
| 3 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 4 | 0 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No |
| 5 | 0 mg | No palpable fibrosis | 1 | No | No | No palpable fibrosis | 2 | No | No | Sacrificed at 4 weeks | |||
| 6 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No |
| 7 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | Sacrificed at 4 weeks | |||
| 8 | 0 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No |
| 9 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 10 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No |
| 11 | 0 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | Sacrificed at 4 weeks | |||
| 12 | 0 mg | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 4 | No | No |
| 13 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | Sacrificed at 4 weeks | |||
| 14 | 16 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 2 | No | No |
| 15 | 16 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 16 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 4 | No | No |
| 17 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 18 | 16 mg | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 4 | No | No |
| 19 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | Sacrificed at 4 weeks | |||
| 20 | 16 mg | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 5 | No | No | No palpable fibrosis | 5 | No | No |
| 21 | 16 mg | No palpable fibrosis | 5 | No | No | No palpable fibrosis | 5 | No | No | Sacrificed at 4 weeks | |||
| 22 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 4 | No | No | No palpable fibrosis | 5 | No | No |
| 23 | 16 mg | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 3 | No | No | Sacrificed at 4 weeks | |||
| 24 | 16 mg | No palpable fibrosis | 2 | No | No | No palpable fibrosis | 3 | No | No | No palpable fibrosis | 2 | No | No |
| 25 | 160 mg | No palpable fibrosis | 2 | No | No | 2 cm2 | 6 | No | No | Sacrificed at 4 weeks | |||
| 26 | 160 mg | No palpable fibrosis | 3 | No | No | 4 cm2 | 7 | No | No | 4 cm2 | 7 | No | No |
| 27 | 160 mg | No palpable fibrosis | 4 | No | No | 2 cm2 | 5 | No | No | Sacrificed at 4 weeks | |||
| 28 | 160 mg | No palpable fibrosis | 4 | No | No | 2 cm2 | 5 | No | No | 2 cm2 | 5 | No | No |
| 29 | 160 mg | 2 cm2 | 4 | No | No | 3 cm2 | 4 | No | No | Sacrificed at 4 weeks | |||
| 30 | 160 mg | 2 cm2 | 5 | No | No | 3 cm2 | 7 | No | No | 3 cm2 | 7 | No | No |
| 31 | 160 mg | No palpable fibrosis | 2 | No | No | 2 cm2 | 5 | No | No | Sacrificed at 4 weeks | |||
| 32 | 160 mg | No palpable fibrosis | 3 | No | No | 4 cm2 | 6 | No | No | 4 cm2 | 6 | No | No |
| 33 | 160 mg | No palpable fibrosis | 2 | No | No | 4 cm2 | 4 | No | No | Sacrificed at 4 weeks | |||
| 34 | 160 mg | No palpable fibrosis | 3 | No | No | 4 cm2 | 7 | No | No | 4 cm2 | 7 | No | No |
| 35 | 160 mg | No palpable fibrosis | 2 | No | No | 2 cm2 | 7 | No | No | Sacrificed at 4 weeks | |||
| 36 | 160 mg | No palpable fibrosis | 3 | No | No | 3 cm2 | 6 | No | No | 3 cm2 | 7 | No | No |
| 37 | 300 mg | 2 cm2 | 4 | No | No | 4 cm2 | 7 | No | No | Sacrificed at 4 weeks | |||
| 38 | 300 mg | No palpable fibrosis | 4 | No | No | 2 cm2 | 8 | No | No | 3 cm2 | 8 | No | No |
| 39 | 300 mg | No palpable fibrosis | 3 | No | No | 3 cm2 | 6 | No | No | Sacrificed at 4 weeks | |||
| 40 | 300 mg | 2 cm2 | 3 | No | No | 4 cm2 | 5 | No | No | 4 cm2 | 5 | No | No |
| 41 | 300 mg | No palpable fibrosis | 3 | No | No | 2 cm2 | 8 | No | No | Sacrificed at 4 weeks | |||
| 42 | 300 mg | No palpable fibrosis | 3 | No | No | 3 cm2 | 8 | No | No | 3 cm2 | 8 | No | No |
| 43 | 300 mg | No palpable fibrosis | 2 | No | No | 3 cm2 | 7 | No | No | Sacrificed at 4 weeks | |||
| 44 | 300 mg | 2 cm2 | 5 | No | No | 4 cm2 | 7 | No | No | 4 cm2 | 6 | No | No |
| 45 | 300 mg | 2 cm2 | 5 | No | No | 4 cm2 | 8 | No | No | Sacrificed at 4 weeks | |||
| 46 | 300 mg | No palpable fibrosis | 4 | No | No | 3 cm2 | 6 | No | No | 3 cm2 | 6 | No | No |
| 47 | 300 mg | No palpable fibrosis | 3 | No | No | 2 cm2 | 7 | No | No | Sacrificed at 4 weeks | |||
| 48 | 300 mg | 2 cm2 | 4 | No | No | 4 cm2 | 7 | No | No | 4 cm2 | 7 | No | No |