Table 2.

Associations of histidine-rich glycoprotein profiles to various traits in set 3.

Trait	HPA045005		Bsi0137
	Estimatea	P-value	Estimatea	P-value
Aging
Age	0.010	1.53 × 10−6	0.0017	0.44
Mortality risk	1.25	6.45 × 10−5	1.03	0.59
Genetic/protein variants
rs9898 (Pro204Ser)	0.15	2.35 × 10−97	−0.23	1.85 × 10−177
rs1042464 (Asn493Ile)	0.10	1.9 × 10−44	−0.33	<1 × 10−300
Clinical trait
APOA1	−0.26	9.47 × 10−6	−0.01	0.76
APOB	−0.23	8.46 × 10−4	0.30	6.81 × 10−10
C-reactive protein	0.012	7.33 × 10−5	0.0003	0.88
Glucose	−0.028	0.061	0.013	0.21
Hb	−0.008	6.45 × 10−9	0.0004	0.68
HbA1C	−0.047	0.070	0.030	0.092
High density lipoprotein	−0.035	0.41	−0.120	5.65 × 10−5
Low density lipoprotein	−0.044	1.53 × 10−2	0.071	1.90 × 10−8
TC	−0.060	1.37 × 10−4	0.060	4.92 × 10−8
TG	−0.086	2.73 × 10−5	0.074	2.36 × 10−7

^aThe estimates from selected models for individual associations. For clinical traits, the values are the estimated slope from linear regression models with adjustment for age and the top single-nucleotide polymorphism (rs9898 for HPA045005 and rs1042464 for BSI0137). Linear models were also used for age and genetic/protein variants, whereas Cox models for mortality risk (more details in the Materials and Methods section). For the trait, hazard ratios are presented in the column.

The two distinct histidin-rich glycoprotein profiles were compared with respect to the association with various traits in set 3, which are 2,999 samples from the TwinGene cohort (Lichtenstein et al, 2002; Magnusson et al, 2013).