Table 4.
Multivariable Linear Regression Analysis of Systolic and Diastolic Blood Pressure Z-Scores with Log Transformed Urinary BPA and Phthalate Metabolites
| Chemical (N=452) | Changes in Systolic Blood Pressure Z-Scores (95% CI) | Changes in Diastolic Blood Pressure Z-Scores (95% CI) |
|---|---|---|
| BPA | −0.004 (−0.08, 0.07) | −0.02 (−0.09, 0.05) |
| Single Phthalate Metabolites | ||
| PA | 0.01 (−0.05, 0.07) | 0.001 (−0.05, 0.06) |
| MMP | −0.03 (−0.12, 0.07) | −0.05 (−0.15, 0.04) |
| MEP | 0.01 (−0.07, 0.09) | −0.01 (−0.09, 0.06) |
| MCPP | −0.06 (−0.17, 0.05) | −0.02 (−0.13, 0.08) |
| MBP | −0.04 (−0.16, 0.08) | 0.01 (−0.11, 0.12) |
| MIBP | −0.11† (−0.21, −0.01) | −0.05 (−0.15, 0.04) |
| MECPP | 0.03 (−0.03, 0.09) | 0.01 (−0.05, 0.06) |
| MEHHP | 0.02 (−0.06, 0.10) | 0.03 (−0.04, 0.11) |
| MEOHP | 0.02 (−0.05, 0.08) | 0.02 (−0.04, 0.09) |
| MBZP | −0.03 (−0.12, 0.06) | −0.03 (−0.12, 0.06) |
| MHXP | −0.002 (−0.07, 0.06) | −0.01 (−0.07, 0.05) |
| MHPP | −0.07† (−0.13, −0.01) | −0.05 (−0.11, 0.005) |
| MCMHP | −0.03 (−0.12, 0.06) | −0.0004 (−0.09, 0.09) |
| MCHPP | −0.04 (−0.10, 0.02) | −0.02 (−0.08, 0.03) |
| MIDP | −0.02 (−0.06, 0.02) | −0.01 (−0.04, 0.03) |
| MIPRP | −0.01 (−0.07, 0.04) | −0.03 (−0.08, 0.03) |
| Combined Phthalate Metabolites | ||
| LMW Phthalates | 0.01 (−0.10, 0.11) | −0.01 (−0.11, 0.09) |
| HMW Phthalates | −0.02 (−0.13, 0.08) | 0.01 (−0.09, 0.11) |
| DEHP Metabolites | −0.002 (−0.10, 0.09) | 0.01 (−0.08, 0.10) |
| DOP Metabolites | −0.05 (−0.15, 0.06) | −0.02 (−0.11, 0.08) |
Adjusted for the following covariates: sex, age at visit, race, ethnicity, glomerular disease, birth weight, low birth weight, prematurity, BMI z-score, use of ACE-I/ARB, urinary creatinine, and urinary cotinine.
†
The p-value <0.05 but exceeds Bonferroni-corrected p-value <0.01.