Table 5.
Multivariable Linear Regression Analysis of Estimated Glomerular Filtration Rate (ml/min|1.73m2) with Log Transformed Urinary BPA and Phthalate Metabolites
| Chemical (N=451) | eGFR Changes (95% CI) |
|---|---|
| BPA | −0.70 (−1.87, 0.47) |
| Single Phthalate Metabolites | |
| PA | 0.56 (−0.36, 1.49) |
| MMP | 3.96 (2.45, 5.48) P<0.001 |
| MEP | 1.84 (0.60, 3.09) P=0.004 |
| MCPP | 1.24 (−0.48, 2.95) |
| MBP | 2.26† (0.39, 4.13) |
| MIBP | 5.26 (3.76, 6.77) P<0.001 |
| MECPP | 2.35 (1.44, 3.26) P<0.001 |
| MEHHP | 2.40 (1.15, 3.64) P<0.001 |
| MEOHP | 1.85 (0.78, 2.91) P =0.001 |
| MBZP | −0.35 (−1.85, 1.14) |
| MHXP | 1.15† (0.13, 2.17) |
| MHPP | 2.00 (1.08, 2.93) P<0.001 |
| MCMHP | −2.30 (−3.74, −0.85) P=0.002 |
| MCHPP | −1.55 (−2.49, −0.61) P =0.001 |
| MIDP | −0.44 (−1.02, 0.13) |
| MIPRP | 0.81 (−0.10, 1.72) |
| Combined Phthalate Metabolites | |
| LMW Phthalates | 3.46 (1.85, 5.07) P<0.001 |
| HMW Phthalates | 0.39 (−1.30, 2.09) |
| DEHP Metabolites | 1.01 (−0.51, 2.53) |
| DOP Metabolites | −0.80 (−2.42, 0.82) |
Adjusted for the following covariates: sex, age at visit, race, ethnicity, glomerular disease, birth weight, low birth weight, prematurity, BMI z-score, use of ACE-I/ARB, SBP and DBP z-scores, urinary creatinine, and urinary cotinine.
†
The p-value <0.05 but exceeds Bonferroni-corrected p-value <0.01.