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Selenoprotein P causes VEGF resistance and impairs vasculogenesis through reductive stress. In HUVECs, ROS burst is required for VEGF signal transduction by shutting down phosphatase PTP1B. Selenoprotein P scavenges the ROS burst required for signal transduction and thereby induces “VEGF resistance” in endothelial cells (13). HUVECs, human umbilical vein endothelial cells. Color images are available online.
