Table 1.
Patient demographic and clinical data. The data is presented for all patients, responders (overall survival [OS] > 14.9 months), and non-responders (OS < 14.9 months). The reported p-value is the result of Mann-Whitney U-test (MWU) (continuous variables) and Fisher exact test (categorical variables) comparing differences between responders and non-responders
| Characteristic | All patients median (range) | Responders (OS > 14.9 months) median (range) | Non-responders (OS < 14.9 months) median (range) | p-value |
|---|---|---|---|---|
| Number of patients | 30 | 16 | 14 | |
| Age [years] | 65 (46–77) | 67 (48–76) | 61 (46–77) | 0.298 |
| PD-L1 TPS [%] | 75 (3–100) | 77.5 (3–100) | 75 (10–100) | 0.933 |
| Sex | 0.715 | |||
| Female | 15 | 9 | 6 | |
| Male | 15 | 7 | 8 | |
| Histology | 0.532 | |||
| Adenocarcinoma | 17 | 8 | 9 | |
| Squamous cell carcinoma | 8 | 4 | 4 | |
| Other | 5 | 4 | 1 | |
| Smoking status | 0.672 | |||
| Never | 1 | 0 | 1 | |
| Former > 3 years ago | 12 | 7 | 5 | |
| Former < 3 years ago | 5 | 3 | 2 | |
| Until current disease | 8 | 3 | 5 | |
| Current smoker | 4 | 3 | 1 | |
| ECOG PS | 0.162 | |||
| 0 | 8 | 2 | 6 | |
| 1 | 18 | 12 | 6 | |
| 2 | 4 | 2 | 2 | |
| Line of treatment (immunotherapy) | 0.096 | |||
| 1st | 15 | 10 | 5 | |
| 2nd | 13 | 4 | 9 | |
| 3rd | 2 | 2 | 0 | |
| Palliative RT during treatment | 0.657 | |||
| No | 24 | 12 | 12 | |
| Yes | 6 | 4 | 2 | |
ECOG PS = Eastern Cooperative Oncology Group performance status; RT = radiotherapy; TPS = tumour proportion score (TPS)