Table 3.
Baseline radiomics features of primary tumours – univariate and multivariate Cox proportional hazards regression analysis (Cox PH). For each radiomics feature, the hazard ratio (HR), corresponding 95% confidence interval (CI), and p-value of univariate analysis are reported. The 2-variable multivariate regression model was chosen based on the Akaike information criterion (AIC). In order to achieve comparable HRs, all radiomics features were normalized into z-scores
| Feature | Univariate HR (95% CI) | Univariate p-value | Multivariate HR (95% CI) | Multivariate p-value |
|---|---|---|---|---|
| Volume | 1.6 (1.1–2.4) | 0.015 | ||
| SUVmax | 0.77 (0.46–1.3) | 0.320 | ||
| Sum Entropy | 0.96 (0.60–1.5) | 0.860 | ||
| Entropy-GLCM | 1.4 (0.82–2.3) | 0.230 | ||
| Difference entropy | 0.62 (0.40–0.97) | 0.037 | 0.54 (0.31–0.93) | 0.026 |
| Small Run Emphasis (SRE) | 0.46 (0.26–0.81) | 0.007 | 0.39 (0.20–0.76) | 0.006 |
GLCM = Grey-Level Co-occurrence Matrix; SUVmax = maximum standardized uptake value