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. 2020 Aug 5;19:180. doi: 10.1186/s12944-020-01357-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Comparison of the effect of quercetin with the activity of the ET_AR antagonist BQ-123 on blood pressure and outcomes in RUPP rats. BQ-123 abolishes the increase in systolic (a) and diastolic (b) blood pressure. Values were measured at day 19 of gestation. Fetal resorptions (c), fetal body weight (d), placental weight (e) and fetal/placental weight ratio (f) and were determined in pregnant rats at day 21 of gestation. n = 6 for each group in (a-c), n = 53, 26, 29 and 45 pups in control, RUPP, RUPP+Quercetin (50 mg/kg) and RUPP+BQ-123 group respectively in (d-f). Data were shown as mean ± SD. *P < 0.05 compared with the Control group; ^&P < 0.05 compared with the RUPP group. One-way ANOVA with a Tukey’s post hoc test (a, b, d-f), Kruskal-Wallis test (c)