Table 2.

Pharmacokinetic parameters after multiple administration of Mangiferin calcium salt (MCS) and mangiferin in rats (n = 6)

Parameters	Mangiferin calcium salt (MCS)	Mangiferin
	240 mg/kg (Mean ± SD)
AUC(0-t)(μg/L·h)	27,871.50 ± 9197.60*	9075.00 ± 2631.75
AUC(0-∞)(μg/L·h)	30,789.48 ± 11,084.21*	9729.04 ± 2724.13
MRT(0-t)(h)	7.31 ± 1.82	6.93 ± 0.97
MRT(0-∞)(h)	9.77 ± 2.40	8.63 ± 1.05
T1/2(kα)(h)	0.77 ± 0.08	0.84 ± 0.11
T1/2(ke)(h)	5.54 ± 0.72	4.92 ± 0.63
Tmax(h)	3.02 ± 0.09*	4.05 ± 0.36
Cssmin(μg/ml)	0.12 ± 0.02*	0.03 ± 0.01
Cmax(μg/ml)	3.42 ± 1.19*	1.16 ± 0.20
Cavg(μg/ml)	1.16 ± 0.09*	0.38 ± 0.03
V/F(c) (L/kg)	75.73 ± 18.93*	215.53 ± 40.95
CL/F(S)(L/kg·h)	9.48 ± 1.52*	30.36 ± 8.50
FI(%)	2.84 ± 0.19	2.97 ± 0.21

Compared with mangiferin group, *p < 0.05