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. 2020 Aug 6;18:307. doi: 10.1186/s12967-020-02473-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Gene expression patterns in normal individuals, patients with LUSC, and PDX models. a A heat map of gene expression patterns in the tissues samples from normal individuals, patients with LUSC, and PDX models. Clustering was made by sample types: C1 for the samples from the patients with LUSC, C2 for the normal tissue samples and several tumor samples from patients with LUSC, and C3 for the tumor samples from the patients with LUSC and PDX models. Orange indicates normal tissue samples, red indicates tumor samples, gold indicates PDX passage 0, pink indicates PDX passage 1, green indicates PDX passage 2, and light green indicates PDX passage 3. The signaling pathway was generated by functional annotation in the Database for Annotation, Visualization and Integrated Discovery (DAVID) website. b Heat map for SP_079 and SP_100 models in the red boxes from A. c DEGs between the patients with LUSC and PDX models. The Venn diagram represents the 10 most upregulated or downregulated genes in the patients with LUSC and PDX models