Table 1.
Clinical characteristics between successful and failed PDX engraftment
| N = 139 | PDX success | PDX failure | p value |
|---|---|---|---|
|
Age(years) Mean |
66.4 ± 6.8 | 64.8 ± 8.9 | 0.244* |
| Gender | |||
| Male | 60 (96.8%) | 73 (94.8%) | 0.692** |
| Female | 2 (3.2%) | 4(5.2%) | |
| Smoking status | |||
| Former or current | 61 (98.4%) | 76 (98.7%) | 1.000** |
| Never | 1 (1.6%) | 1 (1.3%) | |
| Preoperative Chemotherapy | |||
| Yes | 3 (4.8%) | 13 (16.9%) | 0.033** |
| No | 59 (95.2%) | 64 (83.1%) | |
| pTNM stage (7th) | |||
| I | 18 (29.0%) | 28 (36.4%) | 0.348** |
| II | 29 (46.8%) | 25 (32.5%) | |
| III | 14 (22.6%) | 23 (29.9%) | |
| IV | 1 (1.6%) | 1 (1.3%) | |
| Tumor size | |||
| < 3 cm | 13 (21.0%) | 25 (32.5%) | 0.204** |
| 3 < < 5 | 21 (33.9%) | 27 (35.1%) | |
| 5 < < 7 | 21 (33.9%) | 22 (28.6%) | |
| 7 > | 7 (11.3%) | 3 (3.9%) | |
| Differentiation | |||
| Well | 1 (1.6%) | 1 (1.1%) | 1.000** |
| Moderate | 47 (75.8%) | 58 (76.3%) | |
| Poor | 14 (22.6%) | 17 (22.4%) | |
| Recurrence | |||
| Yes | 14 (22.6%) | 14 (18.2%) | 0.671** |
| No | 48 (77.4%) | 63 (81.8%) | |
| Vascular invasion | |||
| Yes | 8 (12.9%) | 8 (10.4%) | 0.399** |
| No | 54 (87.1%) | 69(92.2%) | |
| Perineural invasion | |||
| Yes | 8 (12.9%) | 6 (7.8%) | 0.399** |
| No | 54 (87.1%) | 71(92.2%) | |
| Lymphatic invasion | |||
| Yes | 22 (35.5%) | 21 (27.3%) | 0.357** |
| No | 40 (64.5%) | 56 (72.7%) | |
| Visceral pleural invasion | |||
| PL0 | 46 (74.2%) | 61 (81.3%) | 0.599** |
| PL1 | 1 (1.6%) | 2 (2.7%) | |
| PL2 | 6 (9.7%) | 6 (8.0%) | |
| PL3 | 9 (14.5%) | 6 (8.0%) | |
The asterisks (*, **) indicate results from a Mann-Whitney U test and a Fisher’s exact test, respectively